The Science Behind MemorySPEX
A New Frontier in Consumer Neurowellness
MemorySPEX® is inspired by a growing body of neuroscience exploring how precisely timed sensory stimulation may influence the brain’s natural activity.
Researchers at MIT and other leading institutions have studied sensory stimulation at 40 Hz, the frequency associated with gamma brain-wave activity. Gamma oscillations are involved in attention, memory, learning and communication between different regions of the brain.
MemorySPEX is designed to translate this emerging science into an accessible, non-invasive consumer neurowellness experience—as easy as putting on a pair of glasses.
Why 40 Hz?
Brain cells communicate through electrical rhythms. Gamma oscillations are among the brain’s fastest rhythms and play an important role in coordinating activity across regions involved in cognition.
Published research has found that 40 Hz visual stimulation can entrain, or synchronize, gamma activity beyond the visual cortex and into higher-order regions of the brain. In preclinical studies, researchers have also observed effects involving neuronal and synaptic protection, microglial activity and neuroinflammation.
Early human studies are continuing to investigate the potential effects of 40 Hz sensory stimulation on sleep, cognition and brain health.
What the Research Suggests
Researchers are exploring several potential effects of 40 Hz sensory stimulation:
Gamma Entrainment:
Visual stimulation at 40 Hz has been shown to increase gamma activity in multiple regions of the brain, including areas associated with learning and memory.
Neuronal and Synaptic Health
Preclinical research suggests that repeated 40 Hz stimulation may help protect neurons and the connections between them.
Microglial Activity
Studies in animal models have observed changes in microglia—the brain’s immune cells responsible for responding to damage and clearing cellular waste.
Blood Flow and Brain-Waste Clearance
Emerging research is examining how gamma stimulation may affect cerebral blood flow and the brain’s natural waste-clearance processes.
Sleep
Early human studies have reported encouraging findings involving sleep quality and reduced sleep fragmentation. Larger studies are needed to confirm these results.
The MemorySPEX Approach
MemorySPEX uses liquid-crystal lenses to modulate ambient light at 40 Hz. The system is designed to create precisely timed visual stimulation without placing LEDs directly in front of the eyes.
The result is a simple, wearable approach to emerging gamma-stimulation science—designed for convenient daily use as part of a healthy lifestyle.
MemorySPEX is being introduced as a General Wellness product. Future therapeutic applications would require clinical validation and applicable FDA authorization.
Reviewed by Medical Professionals
Five physicians invested in Hypersence after reviewing the science supporting the MemorySPEX concept.
Physician advisor and investor Dr. Jay Salimath, DO, FACOS, conducted an extensive review of the published literature on 40 Hz stimulation and prepared a detailed research summary for physicians and investors. His review examined findings involving gamma entrainment, neuronal protection, microglial activity, inflammation, blood flow, sleep and cognitive health.
MemorySPEX Research & Technology Deep Dive
Review the supporting scientific research, medical questions and analysis prepared for Hypersence investors and advisors.
DOWNLOAD THE RESEARCH DEEP DIVE
Neurologist Dr. Suresh Kumar has also designed a future clinical study to evaluate MemorySPEX following completion of product development and funding.